长期COVID和COVID疫苗的副作用是否具有相同的病理生理图像和生化途径?
Jean-François Lesgards1, Dominique Cerdan2, Christian Perronne3
1Independent Researcher, 13397 Marseille, France.
International journal of molecular sciences
|August 28, 2025
概括
长期COVID和疫苗的副作用有共同的原因,包括持续的尖端蛋白和免疫失调. 针对RAAS,KKS和补充剂等关键炎症途径可能提供新的治疗方法.
科学领域:
- 免疫学
- 病理生理学
- 药理学
背景情况:
- 在全球范围内,COVID-19 影响了数百万人,造成了广泛的长期COVID症状.
- 长期COVID是由多器官功能障碍引起的,包括神经,心血管和损伤.
- 可能的预测因素包括病毒持久性,内皮功能障碍,组织损伤,免疫失调和肠道失调.
研究的目的:
- 审查长期COVID的病理生理表现.
- 探索长期COVID和疫苗副作用之间的相似之处.
- 确定两种疾病中常见的免疫炎症途径.
主要方法:
- 对COVID-19病理生理学和长期COVID症状的文献综述.
- 分析COVID-19感染和疫苗接种之间的潜在共同机制.
- 确定两种疾病中关键的免疫炎症途径.
主要成果:
- 在SARS-CoV-2和COVID-19疫苗中存在的尖端蛋白质可以持续存在并与ACE2受体和补充系统相互作用.
- 这种相互作用可能会引发广泛的炎症,类似于COVID-19感染.
- 三个关键途径:氨酸 - 血管氨酸 - 氨酸系统 (RAAS),氨酸 - 氨酸 - 氨酸系统 (KKS) 和莱克补充途径.
结论:
- 长期COVID和疫苗的副作用可能具有共同的免疫-炎症途径.
- 尖蛋白的持久性及其与生物系统的相互作用是潜在的常见触发因素.
- 针对RAAS,KKS和乳素补充途径的治疗策略可以为这两种疾病提供新的治疗方法.
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