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Updated: Sep 10, 2025

Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines
10:16

Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines

Published on: October 8, 2015

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BRAF V600E突变对MAPK通路基因表达具有可变的瘤特异性影响,可能影响患者的结果

Sourat Darabi1, Phillip Stafford1,2,3, David R Braxton1

  • 1Hoag Family Cancer Institute, Newport Beach, CA 92663, USA.

International journal of molecular sciences
|August 28, 2025
PubMed
概括

BRAF抑制剂对黑色素瘤有效,但对甲状腺癌没有效果. 这项研究发现,在具有BRAF突变的黑色素瘤中,激活蛋白激酶 (MAPK) 途径增加,但在甲状腺癌中没有,这解释了药物反应的差异.

关键词:
BRAF 突变它们的RNA表达黑色素瘤甲状腺癌整体外基因组测序整体转录组测序

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