菌核和胃癌:一个新兴的联系
Joana Sorino1, Mario Della Mura1, Giuseppe Ingravallo1
1Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.
International journal of molecular sciences
|August 28, 2025
概括
一种与牙疾病有关的细菌Fusobacterium nucleatum越来越多地与胃癌的发展有关. 它的存在与预后不佳相关,并为精确瘤学提供潜在的生物标志物.
科学领域:
- 微生物学
- 癌症学
- 胃肠病学
背景情况:
- 核菌 (F. nucleatum) 是一种格拉姆阴性无氧菌,传统上与牙周病有关.
- 新出现的证据表明F.核在胃癌 (GC) 发病过程中的作用,特别是在H.pylori阴性或高级GC病例中.
- 在胃组织中检测到F. nucleatum,表明与GC发展的潜在联系.
研究的目的:
- 审查F.核素在胃瘤发生中的作用的证据.
- 作为精确瘤学的诊断和预后生物标志物来检查F. nucleatum.
- 在胃组织中概述F. nucleatum的分子检测方法.
主要方法:
- 对F. nucleatum和GC当前证据的文献综述
- 分析F. nucleatum的致癌机制 (例如免疫调节,侵入性).
- 对F. nucleatum的临床相关性评估 (TMB,VTE,预后).
主要成果:
- 通过IL-17/NF-κB信号传递改变瘤微环境,诱导与瘤相关的中性粒细胞 (TAN),并调节PD-L1以逃避免疫.
- 来自F.核细胞感染的细胞外囊 (EV) 增强了瘤细胞的增殖,入侵和迁移.
- F. 核素存在与瘤突变负担 (TMB) 的增加,静脉血栓栓塞 (VTE) 和患者预后的恶化相关.
结论:
- 在胃癌的进展和发病过程中,F. nucleatum发挥着重要作用.
- 在胃癌诊断和预后方面,F. nucleatum具有潜在的价值生物标志物,支持精确瘤学方法.
- 标准化分子检测方法对于评估F. nucleatum在胃癌样本中的临床意义至关重要.
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