腹腔外科手术对肠道微生物群组成和多样性的影响:使用16S rRNA测序的纵向分析
Radu Petru Soroceanu1,2, Daniel Vasile Timofte1,2, Sergiu Timofeiov1,2
1Department of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
International journal of molecular sciences
|August 28, 2025
概括
减肥手术显著改变肠道微生物组成,促进更健康的微生物平衡. 这些变化与手术后肥胖和代谢健康指标的改善有关.
科学领域:
- 微生物组研究
- 代谢手术
- 抗肥胖药物
背景情况:
- 腹部手术是最有效的肥胖治疗方法,
- 肠道微生物群影响新陈代谢调节,并通过减肥手术改变.
研究的目的:
- 评估腹腔镜袖子胃切除术 (LSG) 和Roux-en-Y胃绕道术 (RYGB) 后的动态肠道微生物群变化.
- 在肥胖患者手术后3个月和6个月评估微生物群的变化.
主要方法:
- 这是一项前性,单中心研究.
- 便样本的16S rRNA基因测序 (V3-V4区域)
- 在手术前 (T0),3个月 (T3) 和6个月 (T6) 的分析.
主要成果:
- 在手术后观察到微生物多样性和结构的显著变化.
- 减少了Firmicutes/Bacteroidetes的比率,增加了Actinobacteria,Proteobacteria和Verrucomicrobia的比率.
- 微生物群正常化趋势与BMI和代谢改善相关.
结论:
- 减肥手术可以促进肠道微生物群的持续变化.
- 这些微生物变化可能有助于减肥手术的治疗效果.
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