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iFGF23:cFGF23比率是一个可疑的诊断标记,用于区分急性和慢性病
Joanna Szczykowska-Miller1, Tomasz Hryszko2, Ewa Koc-Żórawska2
11st Department of Nephrology, Transplantation and Internal Medicine with Dialysis Unit, Medical University of Bialystok, ul. Zurawia 14, 15-540 Bialystok, Poland.
International journal of molecular sciences
|August 28, 2025
概括
完整和C端FGF23的比率 (iFGF23:cFGF23) 可以帮助区分急性损伤 (AKI) 和慢性病 (CKD). 然而,在调整其他因素后,该比率不是可靠的独立标志物来区分AKI和CKD.
科学领域:
- 肝脏病学
- 生物化学
- 临床诊断
背景情况:
- 在功能障碍中,FGF23的升高很常见.
- 在AKI与CKD中假设增加FGF23裂变,降低iFGF23:cFGF23比率.
- 关于该比率在诊断 AKI 与 CKD 区分方面的有用性数据有限.
研究的目的:
- 调查IFGF23:cFGF23比率在区分AKI和CKD中的诊断效用.
- 评估AKI和CKD之间的FGF23裂变模式是否不同.
- 要确定IFGF23:cFGF23比率是否是AKI与CKD的独立标志物.
主要方法:
- 在173名血清肌水平异常的患者中进行单中心队列研究.
- 在入院后24小时内使用ELISA测量完整和C端FGF23 (iFGF23,cFGF23).
- 分析了iFGF23:cFGF23比率使用两倍强大的估计方程.
主要成果:
- 在未调整的分析中,AKI与CKD的cFGF23比率较高,iFGF23比率较低 (p=0. 021,p=0. 017).
- 没有观察到IFGF23水平的显著差异.
- 多变量调整使得差异不显著 (p > 0.5),ROC分析显示差异很小 (AUC=0.60).
结论:
- iFGF23:cFGF23比率不是一个可靠的独立标志物来区分AKI和CKD.
- 观察到的FGF23差异可能是由矿物代谢和炎症驱动的,而不是损伤类型.
- 该比率作为AKI与CKD的独立生物标志物具有有限的临床实用性.
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