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相关概念视频

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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这页已由机器翻译。其他页面可能仍然显示为英文。View in English
  1. 首页
  3. 研究领域
  5. 生物科学
  7. 遗传学
  9. 发育遗传学 (包括性别确定)
  11. 用于研究唐氏综合征的脊椎动物和无脊椎动物模型

用于研究唐氏综合征的脊椎动物和无脊椎动物模型

Ann-Charlotte Granholm1

  • 1Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

International journal of molecular sciences
|August 28, 2025

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In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
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In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

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In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

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Embryo Microinjection and Electroporation in the Chordate Ciona intestinalis
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Embryo Microinjection and Electroporation in the Chordate Ciona intestinalis

Published on: October 16, 2016

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在PubMed 上查看摘要

概括
此摘要是机器生成的。

唐氏综合症 (DS) 是一种三形状,导致发育迟缓和早期痴呆. 动物模型对于了解DS病理和开发向疗法至关重要.

科学领域:

  • 遗传学和发育生物学
  • 神经科学
  • 人类疾病的动物模型

背景情况:

  • 唐氏综合征 (DS) 是最常见的可存活的三症,约每600-700名新生儿中就有1名患有该病.
  • 患有阿尔茨海默氏症的人在晚年会出现发育迟缓,先天性心脏缺陷,骨问题和阿尔茨海默氏症类型痴呆症.
  • 目前尚不完全了解DS病理背后的生物机制.

研究的目的:

  • 审查相关且经过充分研究的唐氏综合征动物模型.
  • 讨论通过这些模型发现的DS发病率的分子途径.

主要方法:

  • 对唐氏综合症动物模型的现有文献的审查.
  • 专注于C. elegans,Drosophila,斑马鱼和小鼠中的模型.
  • 在这些模型中识别的分子路径的分析.

主要成果:

  • 已经开发出各种动物模型来研究唐氏综合征.
  • 这些模型有助于发现导致DS相关的发育和年龄相关疾病的分子途径.
  • 对阿尔茨海默氏症类型痴呆症的洞察力已经获得.

结论:

  • 动物模型是调查唐氏综合征复杂生物机制的重要工具.
关键词:
阿尔茨海默病唐氏综合症动物模型染色体三症

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In Vivo Modeling of the Morbid Human Genome using Danio rerio
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  • 使用这些模型的研究正在推动我们对疾病发病率的理解,
    • 神经退行症