间歇性肺部疾病:它是否代表脊柱关节炎患者的真正并发症? 超声单心试验结果
Andrea Delle Sedie1, Linda Carli1, Annamaria Varrecchia2
1Rheumatology Unit, University of Pisa, 56126 Pisa, Italy.
Journal of clinical medicine
|August 28, 2025
概括
肺部超声波 (LUS) 显示,与健康患者相比,脊椎关节炎患者的肺部线不规则性 (PLI) 增加. 吸烟是该群体中PLI较高的唯一临床因素.
科学领域:
- 关节病学
- 肺病学
- 医学成像
背景情况:
- 间歇性肺病 (ILD) 是类风湿性关节炎 (RA) 的常见并发症,也是导致死亡的主要原因.
- 脊椎关节炎 (SpAs) 在疾病负担和治疗方面与RA有相似之处,但ILD的评估具有挑战性.
- 肺部超声波 (LUS) 为评估自身免疫性疾病中的ILD提供了一个有希望的,低辐射的替代方案.
研究的目的:
- 为了确定与健康患者相比,使用LUS的SPA患者的ILD患病率.
- 通过LUS研究SPA患者的ILD指标和临床特征之间的相关性.
主要方法:
- 连续的SPA门诊患者和HS患者接受了LUS,评估了71个肋间间间隙的多线不规则性 (PLI).
- 患者填写了经过验证的呼吸道和整体健康问卷.
- 从医疗记录中收集了包括疾病特征和药物使用在内的临床数据.
主要成果:
- SpA 患者的 PLI 总得分明显高于 HS (p < 0. 001).
- 胸部后部区域比前部和侧部区域显示出更高的PLI;在SpA和HS组中,吸烟预测了更高的PLI.
- 没有发现PLI得分与患者报告的结果,疾病活性,持续时间或MTX/生物药物使用之间的显著相关性,除了前胸PLI和SF-36得分之间的联系.
结论:
- 与健康患者相比,LUS显示PLI的患病率更高.
- 吸烟习惯是研究群体中唯一与PLI增加显著相关的临床特征.
- LUS是评估SPA的ILD的一个有价值的工具,强调吸烟是关键的相关因素.
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