量化评估的间歇性肺异常对肺癌手术后的长期结果的影响
Jae Hyun Jeon1, Joonseok Lee1, Jong Sun Park2
1Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Republic of Korea.
Journal of clinical medicine
|August 28, 2025
概括
在肺癌手术后量化间歇性肺异常 (ILA) 可以预测患者的结果. 在非小细胞肺癌患者中,ILAs的存在,特别是纤维变化,与死亡风险的增加有关.
科学领域:
- 肺病学
- 癌症学
- 放射学
背景情况:
- 在肺癌患者中越来越多地发现间歇性肺异常 (ILA).
- 肺癌手术后量化评估ILA的预后影响需要进一步阐明.
研究的目的:
- 在接受了第一阶段非小细胞肺癌 (NSCLC) 手术的患者中量化评估的间歇性肺异常 (ILA) 的预后意义.
主要方法:
- 用深度学习结构分析量化了1711名第一阶段NSCLC患者的ILA.
- 倾向性得分匹配之前和之后的总生存率 (OS) 进行了比较.
- 分析了肺癌和非癌症死亡的竞争风险.
主要成果:
- 与非ILA组相比,ILA组 (15. 4%) 在匹配前 (82. 5% vs 93. 4%) 和匹配后 (85. 8% vs 91. 1%) 的5年生存率更差.
- ILA与所有原因死亡风险增加1. 52倍相关 (HR 1. 52,95% CI 1. 05- 2. 18).
- 随着ILA纤维化负担的增加,死亡率的非线性增加,ILA组的非癌症死亡率显著增加.
结论:
- 在切除第一阶段的NSCLC中,ILA的定量评估具有预后价值.
- 纤维化间歇性肺部异常与死亡风险的增加特别相关.
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