小儿高血压患者的血压变化和低级炎症
Katarzyna Dziedzic-Jankowska1, Michał Szyszka2, Adam Bujanowicz2
1Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.
Journal of clinical medicine
|August 28, 2025
概括
患有初级高血压的儿童表现出更高的血压变化 (BPV) 和低度炎症. 单细胞与中性细胞的比率 (MNR) 可能表明BPV,而淋巴细胞数量则预测儿科高血压的非浸泡状态.
科学领域:
- 儿童心脏病学
- 高血压研究
- 炎症研究
背景情况:
- 高血压变化 (BPV) 与患有初级高血压 (PH) 的成年人心血管风险有关.
- 儿童PH中BPV和亚临床炎症之间的关系尚不清楚.
研究的目的:
- 在被诊断为初级高血压的儿童中,研究血压变化 (BPV) 与轻度炎症标志物之间的关联.
- 在儿童高血压中识别BPV和非浸泡状态的潜在炎症预测因素.
主要方法:
- 在56名患有PH的儿童和30名健康对照人群中,使用门诊血压监测 (ABPM) 来评估BPV.
- 分析了包括hsCRP在内的炎症标志物,全血细胞计差异 (中性细胞,单细胞,淋巴细胞) 和介质蛋白-18.
- 使用多变量分析和ROC分析来确定BPV指数和炎症标志物之间的关系.
主要成果:
- 与对照组相比,PH患者的hsCRP,中性粒细胞,单细胞,血小板水平显著提高,单细胞与中性粒细胞的比率 (MNR) 较低.
- 在PH组中观察到BPV指数增加,包括24小时ABPMSBPSD和24小时WSBPV.
- 炎症标志物与BPV指数相关;MNR预测了MAP SD,RPI和WDBPV,而单细胞计数和hsCRP也显示了预测值.
结论:
- 在患有初级高血压的儿童中,血压变化显著增加,并与轻度炎症有关.
- 单细胞与中性细胞的比率 (MNR) 可以作为儿童高血压BPV的关键指标.
- 高淋巴细胞数量是PH儿童不浸泡状态的重要预测指标.
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