类似甜味综合症的皮肤病是重叠血液恶性瘤的前体:病例报告和综述
Loredana Elena Stoica1, Mircea Sorin Ciolofan2, Mihaela Roxana Mitroi2
1Department of Dermatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Journal of clinical medicine
|August 28, 2025
概括
在患有骨髓发育综合征 (MDS) 的患者中,类似于甜味综合征 (SS) 的皮肤疾病的诊断可能具有挑战性. 早期的皮质类固醇反应可能表明SS,但对于T细胞淋巴瘤等潜在的血液恶性瘤,进一步的研究至关重要.
科学领域:
- 皮肤病学
- 血液学
- 癌症学
背景情况:
- 甜味症候群 (SS) 是一种罕见的中性友皮肤病.
- 它经常与血液性恶性瘤,特别是骨髓发育综合征 (MDS) 相关.
研究的目的:
- 在患有MDS的患者中报告非典型的SS类皮肤病.
- 在血液恶性瘤的背景下审查SS的文献.
主要方法:
- 一个77岁的男性患有MDS和红斑发疹.
- 一系列的皮肤和骨髓活检, 组织病理学和免疫组织化学分析.
- 专注于SS和血液恶性瘤的文献审查.
主要成果:
- 最初的活检结果不确切;根据形态和皮质类固醇反应临床诊断SS.
- 患者后来出现了外围T细胞非霍奇金淋巴瘤 (NHL) 和血细胞淋巴细胞瘤 (HLH).
- 通过多次活检证实了T细胞NHL的诊断.
结论:
- 在血液病患者中异常的SS类喷发带来了诊断挑战.
- 组织病理学发现可能不存在或不确.
- 皮质类固醇反应可能是早期诊断线索.
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