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心血管风险和糖尿病多神经病的性别差异:匈牙利东北部单中心回顾性研究
Ferenc Sztanek1, Attila Pető2,3, László Imre Tóth1
1Department of Internal Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Journal of clinical medicine
|August 28, 2025
概括
尽管血糖控制类似,但糖尿病感觉运动多神经病变 (DSPN) 在男性中更为常见. 女性的性别与较低的DSPN发病率有关,这突显了糖尿病并发症的性别差异.
科学领域:
- 内分泌学和新陈代谢
- 神经学
- 心脏病学
背景情况:
- 糖尿病感觉运动多神经病 (DSPN) 是一种影响生活质量的常见糖尿病并发症.
- 关于与DSPN相关的性别特异性心血管风险的数据有限,特别是在中东欧人群中.
研究的目的:
- 研究心血管风险特征的性别差异及其与DSPN的关联.
- 在糖尿病人群中确定DSPN的独立预测因子.
主要方法:
- 对621名1型或2型糖尿病患者的回顾性分析.
- 基于国际标准的DSPN诊断,包括症状评分和电生理学测量.
- 多变量逻辑回归用于识别独立预测因素.
主要成果:
- 在71. 5%的患者中诊断出DSPN,其中58. 2%为女性.
- 男性的心肌梗塞,周围血管疾病和动脉样硬化率较高.
- 女性性别与较低的DSPN发病率独立相关 (OR=0. 592);糖尿病视网膜病变是一个预测因素 (OR=2. 728).
- 电生理学测试显示女性神经传导幅度较低.
结论:
- 在DSPN风险上存在显著的性别差异.
- 为糖尿病患者推个性化查策略,考虑到特定地区的风险因素.
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