肝脏功能障碍患者的高近视是严重肝脏疾病的危险因素:前性队列的证据
Linge Jian1,2,3,4, Zhiqian Huang1,2,3,4, Yu Du1,2,3,4
1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Journal of clinical medicine
|August 28, 2025
概括
高近视或严重近视与肝纤维化和肝硬化风险增加有关. 炎症,特别是C反应蛋白, 部分解释了这种联系.
科学领域:
- 眼科 眼科
- 肝病学
- 系统性炎症
背景情况:
- 高近视越来越多地与全身炎症和代谢功能障碍有关.
- 肝脏是新陈代谢和炎症的中心,可能与高近视共享病理途径.
- 缺乏对高近视度和肝病进展的人口研究.
研究的目的:
- 使用英国生物库数据分析近视严重程度与严重肝病之间的关系.
- 确定炎症标志物或代谢物是否介导高近视和肝脏疾病之间的联系.
- 根据近视的严重程度和肝酶水平进行肝病风险评估.
主要方法:
- 对70,774名英国生物库参与者的前性队列研究持续了14.1年.
- 短视被归类为低至中度,或基于折射误差的高.
- 根据阿斯巴达胺转移酶 (AST) 水平分层的Cox比例危险模型被用于评估肝病风险;调解分析评估了炎症标志物和代谢物.
主要成果:
- 在AST≥40U/ L的参与者中,高近视显著增加肝纤维化和肝硬化风险 (HR=2. 64),呈现剂量依赖的趋势 (Ptrend=0. 004).
- 在AST<40U/ L的参与者中没有发现相关性.
- C反应蛋白 (CRP) 部分调解了这种关联;没有代谢物在校正后存活下来.
结论:
- 在高AST患者中,高近视独立与肝纤维化和肝硬化风险增加有关.
- 与CRP相关的炎症部分介导了这一关联.
- 折射性评估可以帮助分层肝病风险,表明抗炎干预的潜在益处.
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