在多发性硬化眼睛没有视觉神经病史中的斑点内视网膜层的结构和功能评估
Lucilla Barbano1, Lucia Ziccardi1,2, Carmen Dell'Aquila1
1IRCCS-Fondazione Bietti, Via Livenza 1, 00198 Rome, Italy.
Journal of clinical medicine
|August 28, 2025
概括
没有视神经炎的多发性硬化患者在所有斑点区域的视网膜结构和功能都降低了. 这表明即使没有视神经炎,视网膜质细胞 (RGC) 也会受到早期,广泛的损伤.
科学领域:
- 眼科 眼科
- 神经科学
- 视网膜成像
背景情况:
- 在没有视神经炎 (MSnoON) 的多发性硬化患者中,对黄斑内视网膜的研究有限.
- 视网膜质细胞 (RGC) 对于视觉功能至关重要,在神经疾病中可能受到影响.
研究的目的:
- 在MSnoON患者的斑点中研究RGC的局部结构和功能.
- 在MSnoON患者和健康对照者之间比较黄斑内视网膜参数.
主要方法:
- 光学连贯断层扫描 (OCT) 用于测量状细胞层厚度 (GCL+-T).
- 多焦光学负响应 (mfPhNR) 来评估RGC功能 (响应幅度密度,RAD).
- 分析局部斑点区域,包括环和ETDRS部门.
主要成果:
- 与对照组相比,MSnoON患者的斑点GCL+- T和mfPhNR RAD显著降低.
- 在MSnoON患者中,GCL+- T和mfPhNR RAD都具有显著和线性相关性.
- 在所有测试的斑点区域和部门中观察到内视网膜损伤.
结论:
- 多发性硬化可能涉及内光斑的主要形态功能变化,即使没有视神经炎.
- 这种损伤影响所有斑点区域,表明RGC在MS中广泛存在.
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