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Updated: Sep 10, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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在人类肝脏样本中,UGT1A1 mRNA表达与Cis-acting遗传变异和Trans-acting转录调节剂之间的关联

Matthew J Taylor1, Joseph M Collins1, Abelardo D Montalvo1

  • 1Department of Pharmacotherapy and Translational Research, College of Pharmacy, Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville, FL 32610, USA.

Genes
|August 28, 2025
PubMed
概括

在UDP-glucuronosyltransferase1A1 (UGT1A1) 的基因变异对药物代谢的影响不同. 这项研究揭示了影响UGT1A1表达的特定人群调节因素,这对个性化医学至关重要.

关键词:
其他类型血统上的差异基因表达遗传多态性个性化医疗

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