重灌后血糖控制对活体供体肝移植后急性损伤发生率的影响:倾向性得分匹配分析
在PubMed上查看摘要
概括
此摘要是机器生成的。在肝移植后维持最佳血糖 (BG) 水平显著降低了肝移植患者急性损伤 (AKI) 和慢性病 (CKD) 进展的风险.
科学领域
- 肝脏病学
- 肝病学
- 移植医学
背景情况
- 葡萄糖不稳定与肝移植的不良结果有关.
- 肝移植后最佳血糖 (BG) 对急性损伤 (AKI) 的具体影响尚不清楚.
研究的目的
- 研究活体供体肝移植 (LDLT) 后最佳BG水平与AKI发生率之间的关系.
主要方法
- 对3331名LDLT患者的回顾性评估 (2008年至2019年).
- 患者分为最佳的 (110 - 180 mg/ dL) 和非最佳的 (< 110 或 > 180 mg/ dL) 输血后BG组.
- 倾向性得分匹配 (PSM) 和多变量逻辑回归用于分析AKI的发病率,严重程度和慢性病 (CKD) 的进展.
主要成果
- 整体AKI发生率为66. 7%.
- 在PSM之后,最佳BG组的AKI发病率显著降低 (66. 5%与70. 6%,p=0. 032).
- 不理想的BG是AKI (OR1.21) 严重AKI (OR1.32) 和CKD进展的独立风险因素.
结论
- 保持最佳的BG水平与LDLT后AKI的发病率降低有关.
- 最佳的BG管理可以减轻严重AKI的风险,并在一年内进一步发展为CKD.
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