监测心力衰竭的危急病患者的滴氧度
Marek Grochla1,2,3, Marcin Basiak2, Ewa Sztohryn3
1Department of Anesthesiology and Intensive Therapy in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.
Medicina (Kaunas, Lithuania)
|August 28, 2025
概括
常规治疗药物监测 (TDM) 在重症监护室 (ICU) 患者心力衰竭是有益的. 在非幸存者和肝功能障碍患者中观察到较高的狄戈辛水平,这表明TDM优化了剂量并减少了不良反应.
科学领域:
- 药理学
- 危急护理医学
- 心脏病学
背景情况:
- 迪戈辛是一种天然药物,仍在重症监护室使用.
- 在ICU中心力衰竭的治疗通常涉及迪戈辛的使用.
- 在重症患者中对狄戈辛的治疗药物监测 (TDM) 的作用需要评估.
研究的目的:
- 评估常规治疗药物监测 (TDM) 对心力衰竭诊断的ICU患者的有效性.
- 确定影响迪戈辛水平和ICU环境中的患者结果的因素.
主要方法:
- 从2018年1月到2023年7月使用ICU数据库记录的回顾性,单中心研究.
- 纳入标准:103名因心力衰竭而接受迪戈辛治疗的急症监护室患者.
- 排除标准:没有使用狄戈辛,单次测定狄戈辛水平,或没有诊断出心力衰竭.
主要成果:
- 女性接受的狄戈辛剂量明显低于男性 (0. 171±0. 053毫克对比0. 224±0. 080毫克; p < 0. 001).
- 在非幸存者 (1.33 ± 0.59 ng/ mL) 和幸存者 (1.03 ± 0.43 ng/ mL; p = 0.003) 中发现了较高的血清狄戈辛度.
- 与没有肝功能障碍的患者相比,患有肝功能衰竭的患者表现出较高的狄戈辛水平 (1. 31 ± 0. 58 ng/ ml; p = 0. 016).
结论:
- 患有多器官衰竭和肝功能障碍的ICU患者往往会达到较高的血清狄戈辛度.
- 在ICU患者的常规TDM是优化剂量和尽量减少不良影响的好处.
- 根据性别,肝功能和重症监护机构的患者生存情况,可能需要调整digoxin的剂量.
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