在冠状动脉疾病患者中反映系统性动脉样
Horea-Laurentiu Onea1,2, Calin Homorodean1,3, Florin-Leontin Lazar1,2
14th Department of Internal Medicine Medical Clinic No.1, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Medicina (Kaunas, Lithuania)
|August 28, 2025
概括
在冠状动脉疾病 (CAD) 患者中,血清中加勒-3 (Gal-3) 含量升高,与冠状动脉,动脉和大腿动脉疾病的严重程度相关. 这表明Gal-3可能表明系统性动脉样硬化负担,并有助于风险分层.
科学领域:
- 心血管医学
- 生物标志物
- 动脉样硬化研究
背景情况:
- 加勒-3 (Gal-3) 是一种促炎性细胞因子,与动脉样硬化和心血管不良结果有关.
- 它在冠状动脉疾病 (CAD) 中的作用已被认可,但与全身动脉样硬化相关性需要进一步调查.
研究的目的:
- 在CAD患者中检查血清Gal-3水平.
- 评估CAD严重程度与动脉样硬化关动脉,大腿动脉和辐射动脉之间的相关性.
主要方法:
- 预期招募56名接受冠状动脉扫描的CAD患者.
- 在入院后24小时内测量血清Gal-3.
- 通过血管造影和多个动脉区域的血管超声波评估动脉样硬化的严重程度.
主要成果:
- 与对照组相比,CAD患者和急性冠状动脉综合征 (ACS) 与慢性冠状动脉综合征 (CCS) 患者的Gal-3水平显著更高.
- 加尔-3 度与冠状动脉病变严重程度 (直径缩小,治疗病变严重程度) 之间的正相关性.
- 在高于中位数的Gal-3水平的患者中,与动脉斑块厚度和大腿斑块厚度的正相关性.
结论:
- 在ACS中升高的Gal-3水平与冠状动脉,动脉和大腿动脉的动脉硬化负担相关.
- 在动脉样硬化中,Gal-3 具有潜在的病变严重程度和系统性血管参与的标志物.
- 这些发现支持Gal-3在风险分层和多个血管床的动脉样硬化疾病进展监测中的作用.
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