基于磁共振成像的腰椎间盘生理衰老,一个系统的文献综述
Max H E de Vries1, Inge J M H Caelers2,3, Wouter L W van Hemert1
1Department of Orthopaedic Surgery, Zuyderland Medical Centre, 6162 BG Sittard-Geleen, The Netherlands.
Medicina (Kaunas, Lithuania)
|August 28, 2025
概括
本综述使用MRI概述腰椎间盘 (LIDD) 的生理衰老,详述了从20岁到50岁的生化和结构变化. 它为LIDD建立了一个时间线, 指出50岁后的加速退化.
科学领域:
- 放射学和成像学
- 整形医学
- 生物医学工程
背景情况:
- 椎间盘退化 (IVDD) 是与年龄相关的,但非侵入性地区分生理和病理变化是具有挑战性的.
- 目前的生物化学和组织学分析是侵入性的,限制了它们在临床环境中的使用.
- 磁共振成像 (MRI) 是研究腰椎间盘退化 (LIDD) 的一种非侵入性方法.
研究的目的:
- 系统地审查MRI研究以确定腰椎间盘 (LIVD) 的生理衰老过程.
- 在没有先前脊柱病理或手术的个体中确定LIDD的时间表.
- 在正常老化过程中识别磁盘组成和结构的关键变化.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane数据库中进行系统的文献搜索.
- 选标题和摘要,然后对符合条件的文章进行全文审查.
- 使用ROBINS-I进行偏差风险和牛津证据水平的质量评估.
主要成果:
- 包括38篇文章,证据水平从2b到3b不等.
- 从20岁到50岁建立了生理LIDD时间表,显示了最初的蛋白质糖 (PG) 损失和结构变化.
- 50岁后退化加速,与超结构变化和盘高度,体积和凸度的损失;下腰部水平 (L4/5,L5/S1) 显示出更高的退化.
结论:
- 这篇综述基于MRI发现的腰椎间盘生理衰老.
- 这一过程涉及初始的生化变化 (PG损失),随后是超结构性变化.
- 建议通过前性队列研究进行进一步验证.
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