系统性免疫炎症指数和相关的血液标志物作为2型糖尿病的预后工具
Raluca Cosma-Lăzuran1, Daniel-Corneliu Leucuta2, Mihaela-Simona Popoviciu3,4
1Faculty of Medicine and Pharmacy, University of Oradea, Piața 1 Decembrie Street nr 10, 410073 Oradea, Romania.
Medicina (Kaunas, Lithuania)
|August 28, 2025
概括
血液炎症指数如全身炎症反应指数 (SIRI) 和淋巴细胞对单细胞的比率 (LMR) 可以预测2型糖尿病患者的死亡率. 这些可访问的标志物有助于对T2DM个体的心血管风险进行分层.
科学领域:
- 内分泌学和新陈代谢
- 心血管医学
- 血液学
背景情况:
- 慢性低度炎症是2型糖尿病 (T2DM) 发病和血管并发症的组成部分.
- 建议使用血液学指数 (NLR,dNLR,PLR,LMR,SII,SIRI,AISI) 作为系统性炎症标志物和心血管风险预测指标.
研究的目的:
- 评估T2DM患者微和宏血管并发症的血液炎症指数的预测值.
- 评估这些指数与T2DM心血管死亡率的相关性.
主要方法:
- 对237名T2DM患者进行了回顾性队列研究.
- 对血液学指数与心血管死亡率之间的关联进行评估.
- 使用了接收器操作特征 (ROC) 曲线分析和多重后勤回归.
主要成果:
- 在研究期间有30名患者 (12. 66%) 死亡.
- 在SIRI,LMR,AISI和NLR中,死亡率具有最佳的区分能力 (AUC> 0.65,特异性> 70%).
- 单细胞计数和LMR显示微血管并发症的预测值很小,但很显著.
结论:
- 在T2DM患者中,SIRI,LMR,AISI和NLR与死亡率有显著的关联,具有适度的辨别能力.
- 这些可访问和具有成本效益的血液学标志物可能有助于对T2DM患者的风险分层.
- 建议在潜在的队列中进行进一步的验证.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K
Diabetes: Symptoms, Diagnosis, and Complications
685
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
685
Diabetes Mellitus: Overview and Type I Subtype
3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.2K
Psychoneuroimmunology: Diabetes and Cancer
62
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
62
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
213
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
213
Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K


