艾滋病毒感染者的心血管风险:罗马尼亚的初步病例研究
Manuela Arbune1,2, Alina Plesea-Condratovici3, Anca-Adriana Arbune4,5
1Clinical Medical Department, "Dunarea de Jos" University, 800008 Galati, Romania.
Medicina (Kaunas, Lithuania)
|August 28, 2025
概括
接受抗逆转录病毒治疗 (ART) 的艾滋病毒感染者,即使在较年轻时,也会因炎症和代谢综合征而面临心血管风险增加. 早期查和预防对于控制这种风险至关重要.
科学领域:
- 心脏病学
- 传染性疾病
- 公共卫生
背景情况:
- 抗逆转录病毒治疗 (ART) 增加了艾滋病毒感染者 (PLWH) 的寿命,重点转移到心血管疾病 (CVD) 风险.
- 心血管疾病是一个越来越令人担忧的问题,需要对PLWH在ART上的风险因素进行评估.
研究的目的:
- 评估接受ART治疗的艾滋病毒感染者心血管风险.
- 确定传统和艾滋病毒特异性因素与心血管风险增加之间的关联.
主要方法:
- 在罗马尼亚对112个PLWH的病例研究.
- 40岁以上患者的心血管风险 (CVR) 估计使用抗艾滋药物不良事件数据收集 (D:A:D®) 评分和SCORE2算法.
主要成果:
- 肥胖率高 (24.1%),吸烟率高 (55.4%),体力活动低 (70%).
- 40岁以上的参与者心血管平均年龄比他们的时间年龄大7. 5岁.
- 传统的风险因素和高C反应蛋白与心血管反应率的增加有显著联系.
结论:
- 剩余炎症和代谢综合征增加了PLWH患者的心血管风险,包括年轻,稳定的患者.
- 建议将新陈代谢和心血管风险查纳入常规艾滋病毒治疗中,以进行早期预防和个性化治疗.
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