与心房发展相关的冠状动脉炎症和心上脂肪组织体积
Renáta Gerculy1,2,3,4, Imre Benedek1,2,3,4, István Kovács1,3,4
1Clinic of Cardiology, Mureș County Emergency Clinical Hospital, 540136 Târgu Mureș, Romania.
Diagnostics (Basel, Switzerland)
|August 28, 2025
概括
心上脂肪组织 (EAT) 的增加和心房扩张与心房 (AF) 有关. 心脏计算机断层扫描 (CCT) 标志物如EAT体积,左心房体积指数 (LAVI) 和脂肪衰减指数 (FAI) 可以帮助评估AF风险.
科学领域:
- 心脏病学
- 放射学
- 医学成像
背景情况:
- 前庭动 (AF) 与上心脂肪组织 (EAT) 的增加,前庭扩张和冠状动脉炎症有关,但因果关系尚不清楚.
- 心脏计算机断层扫描 (CCT) 可以精确量化EAT体积,左心室体积指数 (LAVI) 和冠状动脉炎症的脂肪衰减指数 (FAI).
- 这些成像标志物以及冠状动脉疾病报告和数据系统 (CAD-RADS) 可能会提高AF风险分层.
研究的目的:
- 评估患有肌肉膜炎的患者的围心 EAT 量,LAVI,CAD- RADS 和 FAI 分数之间的关联.
- 评估先进的人工智能平台在分析这些心脏成像标记的实用性.
主要方法:
- 对122名接受心痛治疗的患者进行了回顾性分析.
- 患者分为AF (n=42) 和非AF (n=80) 组.
- 使用CaRi-Heart®和syngo.via Frontier®测量了EAT体积 (总体,LA-EAT,BA-EAT),LAVI,CAD-RADS和FAI得分.
主要成果:
- 与非肌痛性肌痛患者相比,肌痛性肌痛患者的EAT,LA- EAT,BA- EAT和LAVI总量显著增加.
- 在ROC分析中,总EAT (AUC=0. 869),LA- EAT (AUC=0. 776),BA- EAT (AUC=0. 703) 和LAVI (AUC=0. 756) 的诊断性能强.
- 在AF患者中观察到更高的FAI得分 (p=0. 044),并趋向于更高的CAD- RADS类别.
结论:
- 增加的EAT量,升高的LAVI和更高的FAI得分与AF有显著的关联,表明结构和炎症基质的结合.
- EAT,LAVI,FAI和CAD-RADS是早期AF风险评估的有价值的非侵入性成像生物标志物.
- 先进的人工智能平台可以对这些标记进行全面分析,从而改善患者分层.
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