评估乳腺癌诊断和病理相关性的简化IVIM扩散成像
Abdullah Hussain Abujamea1, Salma Abdulrahman Salem1, Hend Samir Ibrahim2
1Department of Radiology and Medical Imaging, College of Medicine, King Saud University (KSU), Riyadh 11461, Saudi Arabia.
Diagnostics (Basel, Switzerland)
|August 28, 2025
概括
简化输入素不连贯运动 (IVIM) 扩散权重成像 (DWI) 在区分恶性和良性乳腺病变方面表现有前途. 结合D,D*和f等IVIM参数可以提高诊断准确度,瘤等级显示出一些关联.
科学领域:
- 放射学
- 医学成像
- 癌症学
背景情况:
- 区分恶性和良性乳腺病变对于适当的患者治疗至关重要.
- 输内素不连贯运动 (IVIM) 扩散权重成像 (DWI) 提供了对组织微观结构和微循环的洞察.
- 简化的IVIM参数需要对其在乳腺病变特征的诊断实用性进行评估.
研究的目的:
- 评估简化IVIM-DWI参数的诊断性能,以区分恶性与良性乳腺病变.
- 研究IVIM参数与乳腺瘤临床病理特征之间的关联.
主要方法:
- 对108名多个b值DWIM的妇女进行了回顾性分析.
- 使用专门的软件生成IVIM地图 (ADC_map,D,D*).
- 用于诊断准确性的IVIM参数与组织病理学数据和ROC分析的相关性.
主要成果:
- 与良性病变相比,恶性病变的ADC_map,D和D*值明显较低.
- 一个D,D*和f的综合逻辑回归模型实现了0.725的AUC,优于单个参数.
- 组织学等级是唯一与IVIM指标显著相关的临床病理特征.
结论:
- 简化的IVIM-DWI参数,特别是与扩散相关的参数,在乳腺病变分化中提供了中等的准确性.
- 结合IVIM参数的多变量分析可以提高诊断性能.
- IVIM指标可能反映瘤分化,但对预测分子亚型的有用性有限.
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