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用于组织工程的聚烯纳米纤维的合成,表征和酶结合

Chandana B Shivakumar¹, Nithya Rani Raju¹, Pruthvi G Ramu¹

¹Division of Biochemistry, School of Life Sciences, Mysuru, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India.

|August 28, 2025

概括

表面修饰的聚烯酸纳米纤维膜 (PNF) 具有增强的水友性和更快的降解. 这些改进的特性使它们适合生物医学应用.

科学领域:

生物材料科学
聚合物化学
表面工程

背景情况:

聚烯酸纳米纤维膜 (PNF) 是疏水的,并且缓慢降解,限制了它们的生物医学用途.
通过氨解进行表面修饰,引入氨基组以增强可湿性.

研究的目的:

增强聚烯纳米纤维膜 (PNF) 的水友性和降解速度.
通过将酶结合到它们的表面来提高PNF的生物相容性.

主要方法:

通过电和通过氨解修饰表面合成PNF.
结合素,素和胰腺素到氨解PNF上.
使用SEM,FTIR,EDX和液体位移方法进行特征化.

主要成果:

通过酶活性测试和跨pH/温度稳定性验证了酶结合.
SEM证实了纳米纤维形态;FTIR和EDX表明了成功的功能化.
素PNF的多孔性 (88. 50%) 和水友性 (57. 6°) 增加.
胰腺素-PNF的降解率增加 (34. 61%在第28天).

结论:

酶结合的PNF表现出改善的物理化学特性.
这些修改后的PNF是各种生物医学应用的有希望的候选物.
需要进一步研究以优化结合和体外/体内性能.

关键词:

美国电旋转有酶的纳米纤维聚卡普罗拉克扫描电子显微镜伤口愈合

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