响应光的PLGA微粒可随时释放菌素并提高抗菌效率
Mishal Pokharel1, Abid Neron1, Amit Kumar Dey1
1Department of Biongineering, University of Massachusetts Dartmouth, Dartmouth, MA 02740, USA.
Pharmaceutics
|August 28, 2025
概括
这项研究开发了光激活的聚糖乳酸微粒,用于控制菌素的释放. 接近红外线可以触发药物输送, 提高抗菌效果, 尽量减少副作用.
科学领域:
- 生物材料科学
- 药物输送系统
- 纳米技术
背景情况:
- 优化药物输送系统对于有效治疗和减少副作用至关重要.
- 精确的药物释放,由外界刺激激活,如光,提供增强的治疗控制.
- 对于持续释放药物的应用,正在研究聚乳糖酸 (PLGA) 微粒 (MP).
研究的目的:
- 开发一种使用PLGA微粒进行持续释放的药物输送系统.
- 设计能够对近红外 (NIR) 光响应的微粒,以便按需激活药物.
- 评估基托桑涂层对微粒特性和药物释放动力学的影响.
主要方法:
- 使用双重乳液方法制造PLGA微粒,同时加载胺和绿色氨酸 (ICG).
- 微粒的特征包括大小,表面电荷,形态,稳定性和药物封装效率.
- 通过NIR触发药物释放后的细菌殖民地计数来评估抗菌疗效.
主要成果:
- 基托桑涂层增加了粒子大小和表面电荷,扫描电子显微镜显示了不同的形态.
- 配方PVI1显示出高产率 (76. 67%) 和封装效率 (56. 2%).
- 阳光照射显著增强了菌素的释放,配方PVI4显示出> 48. 9%的释放和改善的抗菌活性;在没有阳光照射的情况下,酸盐涂层的颗粒抑制了释放.
结论:
- 具有酸盐涂层,对NIR反应的PLGA微粒显示出精确,按需的抗生素输送的潜力.
- 通过光触发的菌素释放,开发的系统提供了更好的抗菌性能.
- 药物释放动力学遵循零顺序和科尔斯迈尔- 佩帕斯模型,表明受控释放机制.
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