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用于关节炎治疗的含有黄素和衍生物的纳米载体:在范围审查中绘制证据

Beatriz Yurie Sugisawa Sato¹, Susan Iida Chong¹, Nathalia Marçallo Peixoto Souza²

¹Curso de Biomedicina, Departamento de Análises Clínicas, Universidade Federal do Paraná, Curitiba 80210-170, Brazil.

|August 28, 2025

概括

库尔库明 (CUR) 纳米载体通过提高溶解度和生物可用性来治疗关节炎. 虽然在临床前模型中有效,但需要更多的人体研究来证实临床益处.

科学领域:

药理学
生物医学工程
纳米技术

背景情况:

黄素 (CUR) 具有对关节炎治疗有益的抗氧化和抗炎性质.
低水溶性,不稳定性和低生物可用性限制了CUR的治疗应用.
纳米载体系统为克服CUR的局限性提供了一个有希望的策略.

研究的目的:

对CUR或其衍生物在纳米载体系统中用于关节炎治疗进行范围审查.
评估CUR-纳米载体对关节炎管理的影响.
确定该领域的研究缺口和未来方向.

主要方法:

在PubMed,Scopus和Web of Science中对临床前 (体内) 和临床研究进行系统的文献搜索.
纳米基CUR配方用于关节炎治疗.
分析了34篇精选文章,包括31篇临床前试验和3篇临床试验.

主要成果:

大多数研究都使用在有机纳米载体中封装的纯CUR,特别是纳米颗粒和纳米乳液.
CUR纳米载体表现出增强的溶解性,生物可用性和稳定性,从而提高了药理疗效.
临床前发现表明封装的CUR与其自由形式相比具有更好的结果,但对人类的证据仍然有限.

结论:

含有CUR的纳米载体具有显著的抗关节炎作用,是有前途的治疗替代品.
需要进一步的研究来验证这些发现在人体临床试验中.
在临床前研究中解决数据质量和清晰度对于该领域的进步至关重要.

关键词:

类药物关节的炎症纳米结构可溶性

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