纳米载体在单体药物输送中
Sheila Porto de Matos1, Karen de Oliveira Araujo1, Tainá Kreutz1
1Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, Porto Alegre 90610-000, Brazil.
Pharmaceutics
|August 28, 2025
概括
纳米技术为将药物输送到指甲提供了有前途的解决方案, 然而,缺乏标准化的透性测试, 阻碍了对这些先进的药物输送系统的比较分析.
科学领域:
- 制药科学
- 生物技术
- 皮肤病学
背景情况:
- 爪疾病,如甲状腺和爪病,显著影响患者的生活质量.
- 指甲板的密,质结构形成了一个重要的障碍,使得治疗指甲病的有效药物输送复杂化.
- 目前针对指甲疾病的全身和局部治疗由于指甲的固有特性而面临生物可用性挑战.
研究的目的:
- 审查目前用于局部治疗非口腔疾病的纳米结构药物输送系统.
- 探索旨在提高指甲板内的药物生物可用性的技术进步.
- 确定该领域的挑战和局限性,特别是评估方法.
主要方法:
- 对纳米结构系统进行广泛的文献综述,用于治疗非性疾病.
- 分析改善药物通过指甲屏障的策略.
- 对评估指甲药物透现有方法的评估.
主要成果:
- 基于纳米技术的系统显示出在指甲板中增加药物的生物可用性.
- 将纳米技术与其他方法相结合可能进一步提高药物透率.
- 在研究中发现,指甲透度评估方法缺乏标准化.
结论:
- 纳米结构系统代表了局部治疗非性疾病的有希望的途径.
- 标准化指甲透测试对于评估和比较新药输送系统的有效性至关重要.
- 需要进一步的研究来优化和验证这些纳米技术的临床应用.
相关概念视频
01:22Drug Delivery: Miscellaneous Routes
467
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
467
01:16Drug Delivery: Overview
422
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
422
01:15Non-Oral Extravascular Drug Absorption Routes
294
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
294
01:18Drug Delivery: Enteral Route
709
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
709
01:29Drug Delivery: Parenteral Route
827
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
827
01:23Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
788
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
788