在摩洛哥妇女的HPV驱动性损伤阶段的宫和阴道微生物组动态
Malika Allali1,2, Khaoula Errafii3, Rachid El Fermi3
1Virology and Public Health Laboratory, Institut Pasteur du Maroc, Casablanca 20360, Morocco.
Microorganisms
|August 28, 2025
概括
摩洛哥妇女的宫癌进展与宫和阴道微生物组的重大变化有关. 在癌前和治疗后的阶段观察到,健康的微生物群由乳杆菌主导下降,机会性细菌增加.
科学领域:
- 微生物组研究
- 妇科瘤学
- 传染病流行病学
背景情况:
- 宫癌是摩洛哥妇女的重大健康问题,通常与持续高风险的人类乳头瘤病毒 (hr-HPV) 感染有关.
- 了解宫-阴道微生物组在癌症发育和治疗结果中的作用对于有针对性的干预至关重要.
研究的目的:
- 研究摩洛哥妇女与HPV相关的宫癌不同临床阶段的宫和阴道微生物组的差异.
- 分析HPV感染和治疗对阴道微生物群的组成和功能的影响.
主要方法:
- 使用16S rRNA测序分析了来自247名摩洛哥妇女的宫-阴道样本.
- 参与者包括健康对照者,h-HPV阳性癌前病例和治疗后的宫癌病例.
- 进行统计分析以比较不同组的微生物多样性和组成.
主要成果:
- 与健康对照群相比,在癌症前 (45%) 和治疗后 (50%) 的CC病例中观察到乳酸菌的大量减少.
- 在癌前样本中发现了Pseudomonadota和Actinobacteriota的增加,而治疗后的样本显示了Campylobacteriota和Fusobacteriota的增加.
- 虽然α多样性保持稳定,但β多样性在临床阶段有显著差异 (p = 0. 001),表明不同的微生物群体结构.
结论:
- 在摩洛哥妇女的宫癌进展和治疗后,宫和阴道微生物组的组成发生显著变化.
- 微生物的转移,包括乳杆菌的减少和其他类的增加,与HPV相关的宫病变有关.
- 宿主因素如晚期初潮,高性别平价,性传播感染和避孕药的使用可能会影响这些微生物群的变化.
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