相关实验视频

Updated: Sep 9, 2025

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

唾液C反应蛋白:儿童急性尾炎的非侵入性替代方案

Klaudio Pjer Milunović¹, Lada Stanišić², Tomislav Barić¹

¹Department of Pediatric Surgery, University Hospital of Split, 21000 Split, Croatia.

Molecules (Basel, Switzerland)

|August 28, 2025

概括

唾液C反应蛋白 (CRP) 显示为诊断儿童急性尾炎的非侵入性生物标志物. 它的诊断性能与血液测试相当,可能减少侵入性手术的需要.

科学领域:

儿童医学
生物标志物发现
诊断的准确性

背景情况:

急性尾炎是儿童常见的手术紧急情况.
目前的诊断方法可能涉及诸如血液检测之类的侵袭性手术.
早期和准确的诊断需要非侵入性生物标志物.

研究的目的:

评估唾液C反应蛋白 (CRP) 作为儿童急性尾炎的非侵入性生物标志物.
将唾液CRP水平与血清CRP水平进行比较以确定诊断潜力.
评估唾液和血清CRP之间的诊断性能和一致性.

主要方法:

在确诊尾炎的儿科患者和对照组中测量了唾液和血清CRP水平.
使用接收器操作特征 (ROC) 分析来评估诊断性能.
使用斯皮尔曼相关性和布兰德- 阿尔特曼分析评估了唾液和血清CRP之间的一致性.

主要成果:

与对照组相比,尾炎患者的唾液CRP水平显著升高 (中位数为35. 7对1.1 mg/ l).
唾液CRP显示出优异的分辨能力 (AUC=0. 97),与血清CRP (AUC=0. 98) 相比.
在唾液和血清CRP水平之间观察到强烈的相关性 (斯皮尔曼 ρ = 0. 963) 和良好的一致性.

结论:

唾液CRP是一种有前途的非侵入性生物标志物,用于诊断儿童的急性尾炎.
它的诊断性能与血清CRP可比,表明可能减少侵入性血液采样.
这种方法可以简化儿童紧急情况的早期评估.

关键词:

急性尾炎 c-反应性蛋白诊断的准确性炎症标志物非侵入性诊断儿童手术唾液检测唾液生物标志物血清生物标志物

更多相关视频

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens

Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens

Published on: September 12, 2016

相关概念视频

Appendicitis-I: Introduction

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

Appendicitis-II: Diagnostic Studies and Management

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...