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从土壤中获得的真菌Trichoderma atroviride中分离出的细胞毒性代谢物

Jun Gu Kim¹, Jae Sang Han¹, Dahyeon Lee²

¹College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.

Molecules (Basel, Switzerland)

|August 28, 2025

概括

从Trichoderma atroviride中分离出了12种新的化合物. 化合物1-5对结肠和卵巢癌细胞具有显著的细胞毒性,表明其潜在的治疗用途.

科学领域:

自然产品化学
医学化学
菌群学

背景情况:

土壤真菌是新生物活性化合物的丰富来源.
已知Trichoderma atroviride会产生各种二次代谢物.
类化合物经常表现出强烈的生物活性.

研究的目的:

从Trichoderma atroviride中分离和描述新的化合物.
评估隔离化合物的细胞毒性对癌细胞系的潜在作用.

主要方法:

用于隔离和初步分析的LC-MS (液态色谱-质谱).
1D和2D核磁共振光谱用于结构阐明.
修改了马菲的立体化学分析方法.
对HCT-8 (结肠癌) 和SK-OV-3 (卵巢癌) 细胞系进行细胞毒性测定.

主要成果:

已成功分离出12种未被描述的化合物,分别是bukhansantaibols A-K (1-10) 和bukhansantaibals A-B (11-12).
使用全面的光谱和化学方法确定了所有化合物的结构.
化合物1-5对结肠和卵巢癌细胞具有显著的细胞毒性作用.
活性化合物的IC50值在2. 1至19. 6μM之间.

结论:

特里科德玛亚特罗维里德产生具有有前景的细胞毒性作用的新化合物.
化合物1-5代表了开发新抗癌药物的潜在线索.
对作用机制和结构活动关系进行进一步的研究是有必要的.

关键词:

皮病毒细胞毒性活动类药物土壤真菌结构阐明

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