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Updated: Sep 9, 2025

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi
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针对细菌腺酸激酶mRNA与化学反意义寡核酸进行合理的抗菌药物开发

Lozena A Otcheva1, Martina Traykovska1, Robert Penchovsky1

  • 1Laboratory of Synthetic Biology and Bioinformatics, Faculty of Biology, Sofia University "Saint Kliment Ohridski", 8 Dragan Tzankov Blvd., 1164 Sofia, Bulgaria.

Molecules (Basel, Switzerland)
|August 28, 2025
PubMed
概括

这项研究引入了一种新型的抗菌药物发现方法,该方法使用仿真抗意义寡核酸 (ASO) 来向细菌mRNA. 这种方法对抗多药耐药细菌如金黄色葡萄球菌具有前景.

关键词:
黄金葡萄球菌抗菌药物的开发抗生素耐药性抗生素没有意义的寡核酸多种耐药性细菌

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