蛋白质营养对关键疾病中的肌肉功能的影响:系统审查和元分析
Mohamed A Mohamed1,2, Brett Doleman1,2, Bethan E Phillips1
1Centre of Metabolism, Ageing and Physiology (COMAP), MRC-Versus Arthritis Centre of Musculoskeletal Ageing Research (CMAR) and Nottingham NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Derby DE22 3DT, UK.
Nutrients
|August 28, 2025
概括
在重症监护室 (ICU) 摄入较多的蛋白质可能会改善骨肌肉的强度. 需要更多高质量的试验来证实这种对重症患者肌肉功能的影响.
科学领域:
- 危急护理医学
- 营养科学
- 肌肉生理学
背景情况:
- 危急疾病会改变蛋白质代谢,导致骨肌肉的代谢和功能衰退.
- 虽然蛋白质营养改善了临床结果,但其对重症患者肌肉力量的具体影响尚不清楚.
- 了解蛋白质在肌肉功能中的作用对于优化患者康复至关重要.
研究的目的:
- 在成年重症监护室 (ICU) 检查不同剂量的蛋白质对骨肌肉强度的影响.
- 综合随机对照试验 (RCT) 的证据以确定最佳的蛋白质策略.
- 发现严重疾病中的蛋白质补充和肌肉功能方面的研究缺陷.
主要方法:
- 在五个主要数据库和临床试验注册表中系统搜索相关RCT.
- 包括标准:非怀孕的成年ICU患者,不同剂量的蛋白质,肌肉强度结果.
- 排除标准:仅针对肌肉结构的研究或与其他干预措施相关的研究;五项符合条件的RCT的元分析.
主要成果:
- 在蛋白质摄入量较高和较低的组之间观察到骨肌肉强度的统计学显著差异 (平均差异: 2. 36 公斤).
- 两组蛋白质剂量的平均差异为0. 46g/ kg/ d.
- 包含的研究显示偏差风险中等至高,表明存在相当大的异质性.
结论:
- 蛋白质剂量似乎影响了ICU患者的骨肌肉强度.
- 目前的证据受限于专注于肌肉功能的试验数量和质量.
- 进一步进行高质量的研究是必不可少的,以确定蛋白质治疗的确切建议,以增强严重疾病中的肌肉力量.
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