韩国越来越多的潜在维生素D毒性及其危险因素:一项基于人口的大规模研究
Rihwa Choi1,2, Gayoung Chun3, Sung-Eun Cho4
1Laboratory Medicine Center, Division of Laboratory Medicine, GC Labs, Yongin-si 16924, Republic of Korea.
Nutrients
|August 28, 2025
概括
在韩国,维生素D (25-维生素D) 含量升高的患病率正在增加,尤其是在妇女和老年人中. 这种趋势需要更多的意识和监测, 以防止潜在的维生素D毒性.
科学领域:
- 内分泌学
- 公共卫生
- 营养科学
背景情况:
- 维生素D对于免疫功能,骨健康,心血管健康和癌症预防至关重要.
- 关于韩国血清25-氧维生素D[25-氧维生素D]升高的患病率和危险因素的数据有限.
- 升高的25 (OH) D可能表明潜在的维生素D毒性.
研究的目的:
- 调查韩国血清25OHD度升高的发生率和趋势.
- 确定与潜在的维生素D毒性相关的人口和时间风险因素.
主要方法:
- 在2020年至2022年间对1,198,947人进行检测的实验室数据的回顾性分析.
- 潜在的维生素D毒性定义为血清25 ((OH) D含量>50,100或150 ng/mL.
- 通过多变量逻辑回归分析,根据年龄,性别,月份和年份检查患病率.
主要成果:
- 血清25 ((OH) D>50 ng/mL的患病率从4. 41% (2020) 增加到6. 21% (2022).
- 血清25 ((OH) D> 100 ng/ ml的发生率从0. 09%上升到0. 12%.
- 在女性,儿童 (0 - 9岁) 和成年人 (≥50岁) 中观察到更高的患病率.
结论:
- 虽然维生素D毒性的患病率很低,但观察到持续上升的趋势.
- 需要提高公众意识,进行临床监测和基于指南的补充.
- 为了防止维生素D中毒,应特别注意老年人群.
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