从乳球菌和热球菌衍生后生物通过调节巨极化和骨质细胞生成减轻实验性牙周炎
Hyun-Joo Park1,2, Mi-Kyoung Kim1, Soon Chul Heo1
1Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.
Nutrients
|August 28, 2025
概括
后生菌 Lactococcus lactis HY449 和 Streptococcus thermophilus HY9012 通过调节巨细胞和抑制骨质细胞来减少牙周炎的炎症和骨质损失.
科学领域:
- 微生物学
- 免疫学
- 牙周病学
背景情况:
- 牙周病包括慢性炎症和气泡骨损失.
- 益生菌和后生菌正在作为牙周炎的潜在疗法进行研究.
研究的目的:
- 调查后生菌Lactococcus lactis HY449和Streptococcus thermophilus HY9012对牙周炎的致病作用.
- 阐明它们对巨细胞两极分化和骨质细胞分化的影响.
主要方法:
- 通过 Porphyromonas gingivalis lipopolysaccharide 和后生菌分化为 M1 巨细胞.
- 使用耐酸酸酶染色评估骨质细胞分化.
- 实验中使用了一种因结带引起的牙周炎的小鼠模型.
主要成果:
- 后生菌HY449和HY9012协同抑制了M1的促炎标志物,并增强了M2的抗炎标志物.
- 后生菌抑制骨质细胞分化并降低关键的骨质细胞生成基因.
- 在牙周炎的小鼠模型中,同时治疗减少了膜骨损失.
结论:
- 在治疗牙周炎方面,后生菌HY449和HY9012具有协同作用.
- 这些后生物可以被视为牙周炎的辅助治疗.
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