与胰岛素耐药性相关的ADH1B基因型,酒精消耗和肠道微生物群的相互作用
Brian Wang1, Brandilyn A Peters-Samuelson1, Kai Luo1
1Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
ADH1B基因变异影响酒精代谢和肠道微生物组合. 在非携带这种变体的人群中,肠道微生物群可能会介导酒精对胰岛素抵抗的保护作用.
科学领域:
- 遗传学
- 微生物学
- 代谢过程
背景情况:
- 饮酒与肠道微生物群的变化和胰岛素抵抗有关.
- ADH1B 基因的 rs1229984 变体会影响酒精代谢速度.
- 携带者比不携带者代谢酒精的速度快80倍.
研究的目的:
- 调查ADH1B rs1229984基因型,酒精摄入量,肠道微生物群和胰岛素抵抗之间的联系.
- 确定肠道微生物是否通过ADH1B基因型调解酒精对胰岛素耐药性的影响.
主要方法:
- 来自西班牙裔社区健康研究/拉丁裔研究的体基因组数据的横截面分析.
- 使用微生物组组成分析确定与酒精相关的肠道微生物种类.
- 构建基因型特异性肠道微生物群评分 (GMS),以评估对胰岛素抵抗的调解效应 (HOMA- IR > 2. 5).
主要成果:
- 在ADH1B非载体 (54个物种) 和载体 (16个物种) 中确定了与酒精相关的显著微生物.
- 在非携带者中,GMS改变了酒精-胰岛素耐药性关系 (P相互作用 = 0. 011).
- 像Prevotella copri这样的特定微生物影响了非载体的这种关系.
结论:
- ADH1B rs1229984基因型与酒精改变的肠道微生物群有关.
- 对于非ADH1B载体而言,肠道微生物群可能在酒精消费与胰岛素耐药性之间的保护性关联中发挥作用.
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