在IBD患者的营养状况,微量营养素缺乏和疾病活动之间的关系:多中心的横截面研究
Marco Valvano1,2, Susanna Faenza1, Fabio Cortellini3
1Gastroenterology, Hepatology and Nutrition Division, Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Nutrients
|August 28, 2025
概括
营养状况,包括铁和维生素D水平,与炎症性肠病 (IBD) 活动相关. 然而,在IBD患者中,这些标志物在区分活性和非活性疾病方面表现不佳.
科学领域:
- 胃肠病学
- 临床营养
- 免疫学
背景情况:
- 炎症性肠道疾病 (IBD) 是一种慢性胃肠道疾病,其特征是炎症.
- 炎症状态导致营养不良和营养吸收受损.
- 了解营养状况与疾病活动之间的联系对于患者的治疗至关重要.
研究的目的:
- 评估IBD患者的营养状况,包括微量营养素缺乏和疾病活性之间的关系.
- 评估与营养参数有关的疾病活动的临床和实验室标志物.
- 确定活跃IBD的潜在营养指标.
主要方法:
- 在三个意大利中心进行的横截面研究.
- 收集的基线数据,临床疾病活动和实验室结果.
- 评估的微量营养素 (铁,铁素,维生素B12,维生素D,叶酸),血红蛋白和白蛋白.
- 使用皮尔森相关性和接收器运行特征 (ROC) 分析.
主要成果:
- 分析了110名IBD患者 (40名克罗恩病患者,70名性结肠炎患者).
- 在活跃和不活跃的疾病组之间,血红蛋白,铁,费里丁和维生素D水平有显著差异 (p < 0. 007).
- 在ROC分析中,铁和维生素D的准确度最高 (AUC分别为0. 76和0. 68),但低于最佳值.
结论:
- 血红蛋白,铁,费里丁和维生素D与IBD疾病活动有关.
- 这些标志物在区分活跃和非活跃疾病方面表现不佳.
- 叶酸,维生素B12和白蛋白与疾病活动状态的相关性较差.
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