儿童消化道微生物组的Helicobacter pylori和组成模式:文献综述
Ancuta Lupu1, Anca Adam-Raileanu1, Laura Iulia Bozomitu1
1Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Nutrients
|August 28, 2025
概括
杆菌 (H. pylori) 感染会对人类的微生物群产生全球影响. 研究表明H. pylori及其治疗方法会改变儿童和成年人的肠道细菌,
科学领域:
- 微生物学
- 胃肠病学
- 人类微生物组研究
背景情况:
- 杆菌 (H. pylori) 是一种普遍存在的全球病原体,影响了全球一半以上的人口.
- 尽管进行了广泛的研究,但H. pylori与人类宿主之间的复杂关系仍然不完全理解.
- 杆菌感染,特别是在儿童时期获得的,对人类健康有重大影响.
研究的目的:
- 审查目前对H. pylori与人类微生物群的相互作用的理解.
- 研究H. pylori存在和根除对细菌群落组成的影响.
- 探索基于微生物群调节的个性化医疗方法的潜力.
主要方法:
- 进行了全面的文献审查.
- 在主要的科学数据库中进行了搜索:PubMed/Medline, Web of Science和EMBASE.
- 包括关注H. pylori和人类微生物群的研究报告.
主要成果:
- 人类微生物组与H. pylori之间的关系的确切性质尚不清楚.
- 无论是H. pylori感染还是其根除治疗,都显然会改变细菌群体的组成.
- 这些变化在整个消化道中在儿童和成人群体中都被观察到.
结论:
- 了解微生物组成对于推进个性化医疗策略至关重要.
- 虽然儿科研究有限,但成年人研究结果支持进一步研究儿童的微生物群操纵.
- 向微生物群调节对受H.pylori影响的个体具有有益的健康结果.
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