传染病的化学抗原受体免疫疗法:目前的进展和未来的前景
Maria Kourti1, Paschalis Evangelidis2, Emmanuel Roilides3
1Children & Adolescent Hematology-Oncology Unit, Second Department of Pediatrics, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Pathogens (Basel, Switzerland)
|August 28, 2025
概括
化学抗原受体 (CAR) 细胞疗法在癌症之外具有前景,为慢性感染和自身免疫性疾病提供了新的希望. 研究正在探索CAR工程细胞用于治疗复杂的感染,特别是在免疫功能低下的患者中.
科学领域:
- 免疫学
- 细胞治疗
- 传染性疾病
背景情况:
- 化学抗原受体 (CAR) - T细胞免疫疗法改变了B细胞恶性瘤的治疗方法.
- 新出现的证据表明,CAR工程细胞 (T细胞,NK细胞,巨细胞) 在自身免疫性疾病和固体瘤中具有潜力.
- 慢性感染,多抗药性病原体和免疫力低下个体感染的增加需要新的治疗策略.
研究的目的:
- 对感染性疾病的CAR细胞产品审查当前的临床和临床前数据.
- 突出CAR细胞治疗在治疗慢性感染和传染性并发症方面的潜力.
- 强调在传染病管理中需要个性化治疗.
主要方法:
- 目前正在进行的临床和临床前研究的文献综述.
- 对感染性疾病中的CAR细胞应用数据的分析.
- 关注人类免疫缺陷病毒 (HIV) 感染和其他临床前模型.
主要成果:
- 在临床环境中,CAR免疫疗法主要用于艾滋病毒感染.
- 其他感染的数据主要来自临床前的体外和体内模型.
- 目前正在开发用于治疗慢性感染的CAR细胞疗法.
结论:
- 癌细胞疗法有可能治疗慢性感染和传染性并发症.
- 需要进一步的研究和临床试验来确定各种感染的疗效和安全性.
- 在传染病管理中,CAR细胞疗法是个性化医疗的有希望的途径.
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