格拉姆阴性细菌对塞费皮姆- 恩米塔佐巴克坦的耐药性:一个系统性审查
Matthew E Falagas1,2,3, Laura T Romanos1, Dimitrios S Kontogiannis1
1Alfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, Marousi, 151 23 Athens, Greece.
Pathogens (Basel, Switzerland)
|August 28, 2025
概括
塞菲皮姆- 甲基巴克坦对抗多抗药性格拉姆阴性细菌具有可变的活性. 扩展光谱β- 乳糖酶和安培素Cβ- 乳糖酶生产者的耐药性较低,但碳烯酶和金属β- 乳糖酶生产者的耐药性较高.
科学领域:
- 微生物学
- 传染性疾病
- 药理学
背景情况:
- 新的β-乳酸胺/β-乳酸酶抑制剂组合对于对抗多药耐药 (MDR) 格拉姆阴性细菌至关重要.
- 塞菲皮姆- 甲基乙对各种产生β- 乳糖酶的病原体具有有前途的活性.
研究的目的:
- 系统地审查和评估现有的对塞费皮姆 - 恩米塔巴克坦耐药性的数据.
- 根据特定的β-乳糖酶类型和已确定的断点来分析耐药性.
主要方法:
- 在 Embase,PubMed,Scopus 和 Web of Science 数据库中进行了全面的搜索.
- 使用逆向引用搜索来确定相关的研究.
- 数据的提取和分析遵循了EUCAST和FDA的断点,或研究特定的标准.
主要成果:
- 十项包括15408个分离物体的研究报告了体外敏感性数据.
- 扩展谱β- 乳糖酶 (ESBL) 生产 (0- 2. 8%) 和安培素Cβ- 乳糖酶 (AmpC) 生产 (0%) 隔离物的耐药率较低.
- 在产生素-48β- 乳糖酶 (OXA-48) 的 (3. 4 - 13. 2%),产生Klebsiella pneumoniae carbapenemase (KPC) 的 (36. 7 - 57. 8%) 和产生金属β- 乳糖酶 (MBL) 的 (高达87. 5%) 隔离物中观察到更高的耐药性,特别是NDM和VIM类型.
结论:
- 塞菲皮姆- 甲基对肠杆菌和某些产生ESBL和AmpC酶的阴性病原体具有高活性,使其成为潜在的碳烯节约剂.
- 在使用cefepime- enmetazobactam之前,建议对涉及OXA-48,KPC和MBL分离物的感染进行抗菌敏感性测试.
相关概念视频
Development of Antibiotic Resistance
197
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
197
Bacterial Cell Wall
579
The bacterial cell wall is an essential structural component that encases the plasma membrane, preserving cellular integrity, determining shape, and protecting against osmotic stress. This rigid yet flexible structure primarily comprises peptidoglycan, a polymer that forms a mesh-like matrix conferring mechanical strength and flexibility.Peptidoglycan Composition and StructurePeptidoglycan, the core of the bacterial cell wall, comprises alternating units of N-acetylglucosamine (NAG) and...
579
Antimicrobial Effectiveness
156
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
156
Combined Effects of Drugs: Synergism
4.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.7K


