菌提取物的抗病毒活性不仅仅是由于阿斯丁
Paula Peinsipp1,2, Tanja Gerlza1, Julia Kircher3
1Institute of Pharmaceutical Sciences, University of Graz, Schubertstraße 1, 8010 Graz, Austria.
Pathogens (Basel, Switzerland)
|August 28, 2025
概括
含有阿斯丁的藻类提取物 (ASXr) 和含有低阿斯丁的藻类提取物 (ASXp) 显示出显著的SARS-CoV-2抑制. 这些发现表明微藻生物质具有开发新型抗病毒疗法的潜力.
科学领域:
- 生物化学
- 病毒学
- 自然产品化学
背景情况:
- 阿斯塔桑丁因其抗氧化和潜在的抗病毒特性而闻名.
- 自然存在的阿斯丁通常以ASX-oleoresin的形式使用,ASX-oleoresin是脂肪酸的复杂混合物.
- 在ASX-oleoresin中非阿斯坦丁成分对其生物活性的贡献尚未完全理解.
研究的目的:
- 调查富含阿斯坦丁 (ASXr) 和缺乏阿斯坦丁 (ASXp) 的藻类提取物对SARS-CoV-2的剂量依赖性抗病毒功效.
- 探索ASX-oleoresin与病毒尖端蛋白的结合相互作用.
- 为了确定抗病毒活性是否超出了阿斯塔桑已知的抗氧化作用.
主要方法:
- 使用ASXr (<0. 2%) 和ASXp (20%) 提取物进行体外细胞病毒感染测定.
- 异热度定位以评估ASX-oleoresin与病毒尖端蛋白的结合亲和力.
- 分子动态模拟来分析ASX-oleoresin的结构成分.
主要成果:
- ASXr和ASXp提取物都显示出细胞SARS-CoV-2感染的显著减少.
- 异热度定位显示了ASXr (Kd = 1. 05μM) 和ASXp (Kd = 1. 42μM) 与病毒尖端蛋白的结合亲缘关系.
- 分子动态模拟表明ASX-oleoresin中的脂肪酸域可能充当活动指导因素.
结论:
- 来自Pluvialis血球球菌的ASX-oleoresin分离物具有针对SARS-CoV-2的抗病毒活性,而不依赖于高素含量.
- 抗病毒作用可能通过与病毒尖端蛋白的相互作用,非阿斯塔素成分的贡献.
- 微藻生物质需要进一步研究其在开发新型抗病毒剂方面的潜力.
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