牙周病与非人类灵长类动物的系统性疾病之间的关系
Bruno Pires Miranda1, Amanda Figueira da Silva1, Júlia de Castro Ascenção1
1Oswaldo Cruz Institute, Rio de Janeiro 21040-360, RJ, Brazil.
Veterinary sciences
|August 28, 2025
概括
非人类灵长类动物的牙周病与糖尿病和心脏病等系统性健康问题有关. 慢性炎症和口腔病原体在此起着关键作用.
科学领域:
- 比较病理学
- 生物医学研究中的灵长类模型
- 口腔健康和全身疾病
背景情况:
- 非人类灵长类动物的牙周病反映了人类的情况.
- 对于理解系统性健康影响,NHP模型至关重要.
- 人们越来越认识到口腔健康的系统性影响.
研究的目的:
- 调查牙周病与全身性疾病之间的联系.
- 阐明口腔健康与全身功能障碍之间的联系机制.
- 确定牙周病在NHP中的临床意义.
主要方法:
- 使用PICO策略进行整合性文献审查.
- 包括观察性,实验性和审查性研究.
- 在NHP和系统关联中检查牙周病的研究分析.
主要成果:
- 11项研究证实牙周病与全身疾病 (糖尿病,心血管疾病,骨质疏松症,代谢综合征,妊娠不良后果) 之间存在关联.
- 炎症途径 (细胞因子,急性阶段蛋白质,免疫反应) 调解了这种联系.
- 口腔病原体和慢性炎症影响远处器官,突出显示系统性影响.
结论:
- 在NHP患者中,牙周病有助于全身性疾病的进展.
- 牙周病不仅仅是局部口腔疾病.
- 这些发现支持NHP作为研究口腔系统链接的相关模型.
相关概念视频
01:15Teeth
672
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
672
01:21Tooth Anatomy
1.0K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
1.0K