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Updated: Sep 18, 2025

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脂质纳米颗粒封装TALEN编码mRNA在培养细胞和转基因小鼠中禁用B型肝炎病毒复制

Tiffany Smith1, Prashika Singh1, Ridhwaanah Bhana1

  • 1Wits/SAMRC Antiviral Gene Therapy Research Unit, Infectious Diseases and Oncology Research Institute (IDORI), School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.

Viruses
|August 28, 2025
PubMed
概括

使用转录激活器样效应核酶 (TALENs) 的新基因编辑疗法显示出永久禁用乙型肝炎病毒 (HBV) 协同封闭的圆形DNA (cccDNA) 储存器的前景,为慢性HBV感染提供了潜在的治疗方法.

关键词:
没有HBV其他类型在LNP在TALEN mRNA中cccDNA的使用一个核心

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