在SARS-CoV-2感染和mRNA疫苗接种后的幽默和记忆B细胞反应
Martina Bozhkova1,2, Ralitsa Raycheva3, Steliyan Petrov1,2
1Department of Medical Microbiology and Immunology-"Prof. Dr. Elissay Yanev", Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
mRNA 疫苗和自然 SARS-CoV-2 感染产生类似的 B 细胞记忆反应. mRNA-1273显示出比BNT162b2更持久的免疫力,强调疫苗平台对免疫记忆的影响.
科学领域:
- 免疫学
- 疫苗学
- 病毒学
背景情况:
- 在SARS-CoV-2感染和接种疫苗后评估长期免疫记忆对于公共健康至关重要.
- 抗体水平的下降令人担忧,但记忆B细胞 (MBCs) 和T细胞是持续免疫力的关键.
研究的目的:
- 纵向评估SARS-CoV-2感染和mRNA疫苗接种后免疫记忆的持续时间和质量.
- 在12个月内比较自然感染引起的免疫反应与BNT162b2和mRNA-1273疫苗.
主要方法:
- 在感染或mRNA疫苗接种后对285名参与者的12个月前性研究 (BNT162b2,mRNA-1273).
- 血液样本采集在基线,1-2,6-7,和12-13个月.
- 通过抗RBDIgG,中和抗体,B-ELISPOT和S1特异性MBC流细胞测量来评估免疫反应.
主要成果:
- 与自然感染相比,两种mRNA疫苗都诱导了优异的B细胞和抗体反应.
- 记忆B细胞的频率在6个月达到峰值,下降了12个月,但仍然很高.
- mRNA-1273表现出比BNT162b2更强,更持久的免疫力;自然感染产生了异质的记忆力.
结论:
- mRNA疫苗接种和自然感染诱导类似的记忆B细胞子集扩张.
- 接种疫苗对于对抗SARS-CoV-2的持续免疫记忆至关重要.
- 疫苗平台和剂量显著影响免疫反应的程度和持续时间.
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