在老年人接种COVID-19疫苗后,对SARS-CoV-2的幽默和细胞免疫反应:系统性审查
Ruth Angélica Rojas-De la Cruz1, Janeth M Flores-Córdova1, Cielo Cinthya Calderon-Hernandez1,2,3
1Facultad de Ciencias de la Salud, Carrera de Medicina Humana, Universidad Científica del Sur, Lima 15067, Peru.
Vaccines
|August 28, 2025
概括
老年人接种COVID-19疫苗会增加体内免疫力,但往往会减少细胞反应. 这凸显了为提高疫苗在这个脆弱群体中的有效性而制定定制策略的必要性.
科学领域:
- 免疫学
- 疫苗学
- 老年学
背景情况:
- 关于老年人对SARS-CoV-2疫苗的免疫反应的数据有限.
- 了解这些反应对于优化疫苗接种策略至关重要.
研究的目的:
- 在60岁及以上的个人接受标准和强化COVID-19疫苗接种后分析幽默和细胞免疫反应.
- 综合目前关于老年人群疫苗有效性的证据.
主要方法:
- 在PubMed,Scopus,EMBASE和Web of Science的系统文献搜索.
- 包括临床试验和观察性研究;不包括审查和病例报告.
- 使用纽卡斯尔-太华尺度和偏差风险2.0工具评估研究质量.
主要成果:
- 分析了13项涉及782名老年人的研究,主要使用mRNA疫苗 (Pfizer- BioNTech,Moderna).
- 大多数研究报告了疫苗接种后SARS-CoV-2尖端特异性IgG标位的增加.
- 细胞免疫显示出不同的结果,一些研究报告了干扰素 (IFN-γ) 的增加,而另一些则报告了低水平.
结论:
- 老年人接种COVID-19疫苗通常会增强体内免疫力,但经常显示细胞反应减弱.
- 与年龄相关的免疫衰老可能会影响疫苗诱导的保护的持久性和范围.
- 需要量身定制的疫苗接种策略,以应对新出现的变种并改善老年人的保护.
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