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Updated: Sep 9, 2025

Production of Human CRISPR-Engineered CAR-T Cells
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Production of Human CRISPR-Engineered CAR-T Cells

Published on: March 15, 2021

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针对目标集成和多重基编辑的正交式CRISPR系统可实现异构CAR T细胞的非病毒工程

Nanna S Mikkelsen1, Sujan Ravendran1, Amalie D Broksø1

  • 1Department of Biomedicine, Aarhus University, 8000 Aarhus C., Denmark.

Molecular therapy : the journal of the American Society of Gene Therapy
|August 28, 2025
PubMed
概括

这项研究引入了一种更安全的,双链无断的CRISPR基编辑方法,用于工程化学抗原受体 (CAR) T细胞,增强它们的癌症治疗潜力.

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