相关实验视频
Updated: Sep 9, 2025
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
528
在结肠腺癌中CENPM的表达,预后值和生物功能
Zhiming Cai1, Zhenrong Yang1, Qian Yu2
1Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian, China.
Current medicinal chemistry
|August 28, 2025
概括
中心蛋白M (CENPM) 在结肠腺癌 (COAD) 中过度表达,与患者的生存率更好相关. 这种生物标志物影响细胞循环和瘤微环境,显示出预测免疫治疗反应的潜力.
科学领域:
- 癌症学
- 分子生物学
- 免疫学
背景情况:
- 中心蛋白M (CENPM) 涉及各种癌症,但其在结肠腺癌 (COAD) 中的具体作用在很大程度上尚不清楚.
- 了解CENPM在COAD中的功能对于开发向治疗和改善患者的结果至关重要.
研究的目的:
- 调查CENPM在COAD中的表达模式.
- 确定CENPM在COAD患者的预后意义.
- 阐明CENPM在COAD瘤微环境中的生物功能.
主要方法:
- 对多个数据库进行生物信息分析,以评估CENPM表达及其与COAD的关联.
- 对80名COAD患者的组织微阵列进行免疫组织化学 (IHC) 验证,以将CENPM表达与临床病理特征和存活率相关联.
- 与CENPM表达相关的甲基化状态,细胞循环调节和免疫细胞透的分析.
主要成果:
- 与正常组织相比,COAD组织的CENPM mRNA和蛋白质表达显著增加.
- 较高的CENPM表达与患者的预后改善有关,并被确定为独立的预后因素.
- 通过调节免疫细胞群 (例如CD8+ T细胞,Tregs) 来影响细胞循环调节,影响瘤微环境,并与免疫检查点基因表达相关.
结论:
- 在COAD中,CENPM作为一个重要的独立预后生物标志物,过度表达与更好的生存结果有关.
- 在调节细胞循环和瘤免疫微环境中的CENPM作用表明它有可能作为COAD患者免疫治疗反应的预测生物标志物.
更多相关视频
07:47Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
1.6K
11:49Author Spotlight: Establishing CENP-E Knockout HeLa Cells – A Novel Approach to Study Kinesin-7 CENP-E Biology and its Inhibitors
Published on: June 23, 2023
829
相关概念视频
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
02:07Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K