在肝细胞癌中探索复合Kushen注射的抗癌特性:网络药理学,生物信息学和实验验证的综合方法

在肝细胞癌中探索复合Kushen注射的抗癌特性:网络药理学,生物信息学和实验验证的综合方法

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Changce Wei¹, Chunjuan Zhang¹, Shuyang Wang¹

¹School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China.

Current drug research reviews

|August 28, 2025

概括

复合Kushen注射 (CKI) 可以通过向SRC途径来治疗肝细胞癌 (HCC). 这项研究确定了关键目标并验证了CKI.

科学领域:

癌症学
药理学
生物信息学

背景情况:

肝细胞癌 (HCC) 是一种具有挑战性的治疗结果的原发性肝癌.
由Sophora flavescens和Atractylodes macrocephala获得的复合Kushen注射 (CKI) 用作包括HCC在内的晚期癌症的补充治疗.

研究的目的:

阐明复合Kushen注射 (CKI) 在治疗肝细胞癌 (HCC) 的治疗目标和机制.
结合网络药理学,生物信息学和实验验证以进行全面分析.

主要方法:

使用STRING构建蛋白与蛋白相互作用网络.
使用DAVID和ShinyGO进行基因本体学 (GO) 和KEGG通路分析.
核心目标识别 (CytoHubba),临床相关性评估 (GEPIA2),功能分析 (GMFA,TIMER),分子对接和实验验证 (HepG2细胞).

主要成果:

通过MMP/EGFR/PI3K/AKT途径确定了10个针对CCI的中心目标,其中SRC因其在扩散和迁移中的作用而受到重视.
通过分子对接证实了SRC与CKI的活性化合物 (脱甲基卡,复合) 的相互作用.
在HepG2细胞中的实验验证表明CKI对瘤细胞具有抑制作用.

结论:

通过调节SRC,CCI可能会产生抗HCC效应.
活性化合物脱甲基和溶有关于CKI对HCC的作用机制.

关键词:

复合的库申注射剂美国肝炎G2细胞.生物信息学肝细胞癌网络药理学

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