通过心率时间序列的昼夜标志物预测急性缺血性心力衰竭
Valerie A A van Es1,2,3, Mayke M C J van Leunen1,3, Ignace L J de Lathauwer1,3
1Department of Cardiology, Máxima Medical Centre, Eindhoven, The Netherlands.
ESC heart failure
|August 28, 2025
概括
通过手腕戴式设备检测到的循环节律变化可以提前几周预测急性脱补心力衰竭 (ADHF). 这种早期检测为管理心力衰竭 (HF) 的干预提供了一个窗口.
科学领域:
- 心脏病学
- 生物医学工程
- 时间生物学
背景情况:
- 急性脱补心力衰竭 (ADHF) 的入院率很高,因此需要早期检测方法.
- 影响心率和睡眠的昼夜节律失调可能会在几周前出现恶化的心力衰竭的临床症状.
- 识别这些早期的生理变化可以为干预提供关键的窗口.
研究的目的:
- 开发一个预测算法,用于早期和准确的ADHF检测.
- 调查可穿戴设备的昼夜节律指标的有用性,以预测心力衰竭的脱补偿.
主要方法:
- 在ADHF住院后,65名患者使用手腕戴式设备进行了6个月的监测.
- 循环参数 (尺度,振幅,形) 通过共分析提取.
- 使用21天的事件前数据训练长期短期记忆神经网络,以分类即将发生的HF事件.
主要成果:
- 在HF事件发生前的21天内,观察到显著的昼夜变化,包括半径升高和振幅降低.
- 该分类算法获得了74%的灵敏度,73%的特异性和74%的AUC.
- 减少心率和昼夜节律的幅度是最强的预测因素,占算法的特征重要性的62%.
结论:
- 可穿戴设备的循环指标显示ADHF之前的渐进性变化,表明早期检测的潜力.
- 开发的算法显示了对心力衰竭脱补偿的适度预测性能.
- 建议对更大,多样化的群体和各种传感器类型进行进一步的研究,以完善指标并探索早期干预措施.
更多相关视频
相关概念视频
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
123
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
123
Heart Failure II: Pathophysiology
37
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
37
Heart Failure III: Clinical Manifestations
42
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
42
Pulse rhythm
925
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
925
Heart Failure V: Medical Management
23
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
23
Factors Influencing Heart Rate
4.1K
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
4.1K


