TopoCellGen:使用扩散模型生成细胞拓学
Meilong Xu1, Saumya Gupta1, Xiaoling Hu2
1Stony Brook University, NY, USA.
Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition
|August 28, 2025
概括
本研究引入了一种使用具有拓约束的扩散模型在数字病理学中生成现实的多类细胞拓的新方法. 这种方法改善了细胞分布模拟,并引入了新的度量,即拓格距离 (TopoFD),以更好地评估.
科学领域:
- 数字病理学
- 计算生物学
- 医学成像
背景情况:
- 准确的多类细胞拓模型对于理解组织结构和病理学至关重要.
- 合成细胞拓生成有助于模拟复杂的组织环境并增强训练数据.
- 目前的方法缺乏精确的控制和解释能力,
研究的目的:
- 提出一种创新的方法来生成现实和上下文准确的多类细胞拓.
- 将拓约束集成到扩散模型中,以改进合成细胞布局生成.
- 提高下游应用的细胞拓模拟的精度和可解释性.
主要方法:
- 在扩散模型框架内集成拓约束.
- 细化细胞分布和相互作用模拟.
- 引入一种新的度量,即拓法列距离 (TopoFD),用于评估拓准确性.
主要成果:
- 在生成具有准确拓关系的多类单元格布局方面表现出有效性.
- 在下游任务 (如细胞检测和分类) 中提高了精度和可解释性.
- 验证拟议方法捕获复杂细胞结构的能力.
结论:
- 提出的具有拓约束的扩散模型有效地产生现实的多类细胞拓.
- 新的TopoFD指标提供了与传统指标相比,对拓结构的更高的评估.
- 通过对瘤微环境进行更好的模拟和分析,
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