揭示乳介导机制和心力衰竭病变中的枢纽基因
Hongguang Xie1, Yiqiang Wang2, Xing Zhu2
1School of Traditional Chinese Medicine, Baicheng Medical College, Baicheng, Jilin, China.
Frontiers in cardiovascular medicine
|August 28, 2025
概括
乳显著影响心力衰竭的进展. 六个关键基因 (GATA2,HBB,JAK2,STAT2,STAT4,WARS2) 被确定为HF的潜在生物标志物,与巨分化和炎症有关.
科学领域:
- 生物化学
- 分子生物学
- 心血管研究
背景情况:
- 心力衰竭是一种复杂的心血管疾病,具有显著的发病率和死亡率.
- 乳化是一种后翻译性修饰,因其在细胞过程中的作用越来越被认可,但其在HF病变发生中的特定参与需要阐明.
研究的目的:
- 调查乳酸在心力衰竭 (HF) 的进展中的作用.
- 确定与乳化相关的关键基因 (LRG) 和与HF相关的枢纽基因.
- 探索HF中发现的枢纽基因的诊断潜力和生物学意义.
主要方法:
- 使用了包括177个HF和136个对照样本的GSE57345数据集.
- 进行差异基因表达分析,基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 路径丰富.
- 使用权重基因关联网络分析 (WGCNA),LASSO,XGBoost,Boruta算法和蛋白质-蛋白质相互作用 (PPI) 网络来识别枢纽基因.
- 通过受体操作特征 (ROC) 曲线和基因组丰富分析 (GSEA) 和免疫透分析评估诊断值.
主要成果:
- 在HF样本中发现了91个上调和88个下调的基因,
- 通过与387个LRG交叉不同表达的基因,确定了6个枢纽基因 (GATA2,HBB,JAK2,STAT2,STAT4,WARS2) 涉及乳化介导的HF.
- 通过免疫透分析发现Lcy-HF枢纽基因与巨分化有关.
结论:
- 乳糖在心力衰竭的发病过程中起着至关重要的作用.
- GATA2,HBB,JAK2,STAT2,STAT4和WARS2被确定为HF的潜在乳化生物标志物.
- 乳化-巨分化-炎症轴是推动HF进展的关键机制.
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