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高压氧调节瘤pH,促进铜合基纳米颗粒对抗癌症干细胞

Qingyuan Deng¹, Ao Hua¹, Shiyou Li¹

¹Department of Nanomedicine and Biopharmaceuticals College of Life Science and Technology Huazhong University of Science and Technology Wuhan P. R. China.

Exploration (Beijing, China)

|August 28, 2025

概括

高压氧疗法 (HBO) 结合新型纳米颗粒有效向缺氧瘤中的癌症干细胞 (CSC). 这种方法使瘤的pH值正常化,增强药物输送并抑制CSCs,从而产生强烈的抗瘤作用.

科学领域:

癌症学
生物医学工程
纳米技术

背景情况:

低毒固体瘤会产生酸性细胞外和性细胞内环境,这对癌症干细胞 (CSC) 存活和耐药性至关重要.
碳酸酶9 (CA9) 是这种pH不平衡的关键调节剂,促进CSC自我更新,侵入,迁移和抵抗.
由于瘤复发和转移中的作用,向CSC对于有效的癌症治疗至关重要.

研究的目的:

研究一种新型的抗瘤策略,将高压氧疗法 (HBO) 与基乙醇粉-铜纳米颗粒 (HHD-Cu NPs) 结合起来.
评估这种组合治疗在调节瘤微环境pH值和消除低氧固体瘤中的CSC的有效性.

主要方法:

使用高压氧疗法 (HBO) 克服瘤缺氧并降低像CA9这样的pH调节蛋白.
开发和管理具有双酸反应的基乙烯粉-多克索鲁比辛-铜纳米颗粒 (HHD-CuNP).
评估HBO和HHD-CuNP对瘤细胞和CSC活力,pH调节和药物释放的联合作用.

主要成果:

通过降低CA9的调节和酸性代谢物的积累,HBO治疗导致了瘤细胞和CSC的细胞内酸化.
这种细胞内酸性增强了从HHD-CuNP中释放多克索鲁比辛,并激活了它们的铜介导化学动力效应.
结合疗法显示出瘤生长和CSC群体的强烈抑制,导致显著的抗瘤活性.

结论:

高压氧疗法 (HBO) 可以重新调节瘤pH值,创造有利于向纳米粒子药物输送的环境.
在低氧固体瘤中,HBO与HHD-CuNP的结合提供了一种新且有效的治疗策略.
这种方法有望改善缺氧和大量癌症干细胞的癌症治疗结果.

关键词:

癌症干细胞碳酸无水酶 9 高压氧气纳米医学瘤的pH值

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